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The hypothesis states that tobacco and caffeine both exert their effects by changing the composition of the microbiota in the gut and consequently reducing intestinal inflammation since pro-inflammatory cytokines are also produced by enteric glial cells (EGC) in the gut (Derkinderen et al., 2014)

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Understanding Nicotine Addiction Nicotine addiction is a condition that develops when the body and brain become dependent on nicotine, a chemical found in tobacco products