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This hypothesis that PL induced human pancreatic cancer cell death mainly via the induction of ROS-mediated ferroptosis, on the grounds that the cell death could be suppressed by ferroptosis inhibitors (ferrostatin-1 and liproxstatin-1) and the iron chelator deferoxamine (DFO) (Yamaguchi et al., 2018)

By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling

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Carolina Henritta Pohl, University of the Free State, South Africa Updates Copyright 2016 Liu, Wang, Yu, Li, Liu and Sun