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Network integration and protein structural binding analysis of neurodegeneration-related interactome

Tejedor MT, Garcia-Sobreviela MP, Ledesma M, Arbones-Mainar JM

Analysis of root-mean-square deviation (RMSD) of GLRX over the course of MD simulations before and after each mutation confirmed that the overall fold of GLRX was not altered by these mutations (Supplementary Fig

However, its northward range will be limited by high-altitude barriers, notably the Himalayan mountain range at elevations above 1200 m 77

In addition, reactive oxygen species (ROS) generated in the thyroid during TPO oxidation rise in response to high iodine levels

To understand the catalytic mechanism of the ADP-ribosylhydrolase (ARH) activity of MavL, we screened its active truncation mutants and succeeded in solving the structure of the MavL 40-404 -ADPR complex at a resolution of 2.38 , which revealed that several pairs of hydrogen bonds and a - stacking interaction provided by surrounding amino acids or water molecules are involved in interactions between MavL and ADPR (Supplementary Fig