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People can experience the effects of vitamin B12 deficiency in a range of 156-258 pmol/L (211-350 pg/mL)

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There have been no significant increases in the incidence of opportunistic infections or reactivation of autoimmune diseases in patients undergoing A1AT replacement therapy

Overexpression of the PKC isoform increases the susceptibility of substantia nigra neurons, but PKC inhibitors such as chelerythrine decrease the -synuclein aggregation in dopaminergic cells caused by rotenone (Kabiraj et al., 2015)