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Based upon the data in the study, we propose that CVS is likely the result of cellular hyperexcitability, as a result of a vicious cycle of elevated intracellular cations and mitochondrial dysfunction (Figure 1)

CDK4/6 inhibitor treatment for patients with hormone receptor-positive, HER2negative, advanced or metastatic breast cancer: a US food and drug administration pooled analysis

Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria

Front Neurol 12:769511 Niu YJ, Jiang ZM, Shu H, Li CF, Liu W, Yao GX, Jiang J, Li JQ, Longo A (2002) Assay of carnitine in plasma and urine of healthy adults