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Its copper-chelating properties have made it a subject of interest across multiple areas of preclinical research

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

Front Immunol 11:504077 Scherlie R (2020) Nasal formulations for drug administration and characterization of nasal preparations in drug delivery

To achieve this, there can be only two possibilities: (i) tumor cells may exhibit mechanism(s) removing malonyl-CoA but without directing it toward the fatty acyl synthase machinery, thus relieving carnitine palmitoyltransferase 1 inhibition, and/or (ii) cancers harbor a carnitine palmitoyltransferase 1 that is not sensitive to inhibition by malonyl-CoA

10.1172/JCI38940 15 ChangC.WorleyB

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