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The results revealed a double-edged sword effect: administration of RvE1 on days 17 post-MI improved cardiac function, whereas the same dosage administered on days 714 markedly impaired recovery

Starting with the finding that isolated rat hepatocytes metabolize morphine to various compounds (morphinone-glutathione conjugate, normorphine, and morphinone), the addition of morphine to the isolated hepatocytes induced a marked decrease in the level of intracellular glutathione (GSH) and resulted in cell death