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As a pervasive and indispensable constituent of cellular membranes, cholesterol plays a pivotal role in regulating membrane structure and fluidity (Song et al., 2021)

This occurs through the impairment of thioredoxin 2 (Trx2) activity, which subsequently triggers the release of a cascade of proapoptotic factors, including the notable cyclophilin D, thereby influencing the apoptotic pathways and cellular homeostasis

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Thus, those that inhibit System X c activity are able to inhibit GSH biosynthesis through Cys depletion

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However, 2-DG was used in some clinical trials for cancers or solid tumors 12,13