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To elucidate the molecular mechanisms of these polyphenols, their protein targets were identified using the SuperPred database, which provided UniProt IDs, and the STRING database, which facilitated the mapping of target gene names

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

The phosphorylation of IRS - 1 leads to the recruitment and activation of phosphatidylinositol 3 - kinase (PI3K), which then phosphorylates Akt

Quantification of pathway activity followed by z-normalization was performed using the ssGSEA function in the gseapy library in Python 127

NAC supplements N-acetyl cysteine (NAC) is another amino acid and critical antioxidant