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Similarly, decreased ClC-3 expression enhances mitochondrial membrane permeability [65]

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With the homozygous pGSH1-URA3 strain, a ~ 50% increase of GSH cellular content was observed in cultures supplemented with 100 g/ml 5-FOA, and this increase was relatively stable compared to that of the previous heterozygous strain (Figure S4A)

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Although the specific DNA lesions were not identified, the heightened vulnerability of mtDNA was further supported by experiments using isolated mitochondria, where blue light exposure led to a time-dependent increase in ROS production, such as O 2 , 1 O 2 and OH