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492 Mutant IDH abnormally accumulates D-2-hydroxyglutarate (D-2-HG), triggering epigenetic reprogramming and blockade of cell differentiation, which are particularly prominent in gliomas and hematological malignancies

doi: 10.1038/s41591-018-0316-z 295 AmannJVetterDBlombergSNChristensenHCCoffeeMGerkeSet al

The figures ( Figures 1 , 2 ), created with BioRender.com, significantly enhance the clarity of our study

Increase ability to create muscle and an inhibition of breakdown of muscle has been found with use of Ipamorelin (1)

This leads to the accumulation of tyrosine and toxic upstream intermediates such as succinylacetone, visible in urinary organic acids

Padilla MA, Elobeid M, Ruden DM, Allison DB (2010) An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02