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Based on pathologic, and virologic similarities (monkey pox, vaccinia, cow pox, and variola are members of the genus orthopox virus, and can infect humans and cause cutaneous lesions), it would seem that smallpox lesions also develop, in part, by apoptotic processes

[DOI] [PubMed] [Google Scholar] 80.Virmani M.A., Caso V., Spadoni A., Rossi S., Russo F., Gaetani F

Immunofluorescence staining and imaging Cells in AX12 were fixed using 4% paraformaldehyde in distilled PBS- (PBS without calcium and magnesium)

Hunsaker, L.A