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This protective mechanism may be beneficial in early stages of ischemia

Another great read is the GHRP-2 Ipamorelin discussion

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10.1111/jre.12972 96 SakaiE.Shimada-SugawaraM.NishishitaK.FukumaY.NaitoM.OkamotoK.et al (2012)

This downregulation appears to be an early event independent of neuronal death, potentially mediated by thrombin-induced ACSL4 degradation and ferroptosis promotion (136)