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THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION

Ni 2+ -loaded chelating Sepharose was used for the affinity purification of the target protein (Figure 2B, lanes 13 right )

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doi: 10.1038/ng.3340 72

Cross-comparison of these datasets identified three histone acetyl marksH3K23ac, H4K8ac and H4K12acthat were specifically sensitive to regulation by the KGTMLHEcarnitine axis and validated in multiple cell lines under different conditions (Fig