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C.Shafiee ArdestaniM.RademacherL.KaulM.ApartsinE.et al (2022)

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With regards to NaCl resorption, it has been demonstrated that superoxide stimulates the thick ascending limb of the loop of Henle (TALH) uptake of sodium, a process nitric oxide (NO) inhibits [181,182,183]

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Specifically, male patients exhibited a wider range of disrupted metabolic pathways compared to female patients with the same mutation, when compared to age- and sex-matched HCs