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10.1186/s12951-022-01264-5 193 LiW.-J.ChenH.TongM.-L.NiuJ.-J.ZhuX.-Z.LinL.-R

One trial on astaxanthin supplementation reported no reduction in SDF compared to placebo [81], while another on folic acid reported SDF improvement only in carriers of MTHFR gene 677 thymidine/thymidine polymorphism [82]