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(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

Furthermore, trichothecenes have been linked to a reduced intestinal level of IL-8, which is in charge of eliminating pathogens (Verbrugghe et al., 2012)

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