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31 Predicting drug elimination based on half-life can go awry when very high doses of drugs are used, 32 as in the case of fluoxetine and the treatment of obsessive-compulsive disorder and when drugs are consumed in overdose

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In addition, when neuronal activity in certain brain regions becomes extremely high, and the energy demand exceeds the rate of aerobic glucose oxidation, neurons rapidly take up and use lactate

We [have] never observed responses to PI3K inhibitors in mouse models of pancreatic cancer, since this type of cancer rarely has PI3K mutations, he said

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