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Thus, the receptor NTD FxxLF motif [Figure 10B] is more effective at forming a charge clamp with Glu898 and Lys721 and burying the phenylalanine residues into the AF2 pocket, whereas peptides containing the sequence LxxLL make weaker and fewer contacts with the LBD

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65 Despite efforts have been made to repair mtDNA with various mechanisms, the mutation rate of mtDNA remains higher than nuclear DNA