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10.1007/s12013-014-0365-y 15 BagiZ.FeherA.BeleznaiT

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

By limiting the availability of reduced GSH and NADPH, G6PD deficiency negatively impacts recycling of peroxidized lipids through the glyoxalase pathway and aldehyde dehydrogenase 1 (ALDH1)-dependent steps (Figure 7D)