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Autocrine VEGF signaling in CCs involving VEGF-A/VEGFR-2 interaction has been associated with the maintenance of CSC populations in various cancer types, enabling their resistance to therapy and facilitating tumor recurrence [130]

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The plasma rich with growth factors is then extracted and injected into the inflamed tendon accurately under ultrasound guidance

This application is earlier-stage than tendon or gut data, but is generating significant interest for post-injury nerve recovery protocols

It can be difficult to detect on imaging due to local invasion of bile ducts rather than formation of a tumour in the early stages