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Figure 2 2.1 The primary factor contributing to the deterioration in oocyte quality is the elevation in oxidative stress In women of advanced reproductive age, oocytes demonstrate elevated levels of reactive ROS as a consequence of mitochondrial dysfunction

Gender also seems to play a role with more prevalence of the disease among the females than the males in the developing nations indicating that societal norms may also play a role

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3 With elucidation of its mechanism, incidence, and impact on resistance to chemotherapy, interventions to decrease target concentrations of GSH may become part of future oncologic therapeutic regimens