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Ferroptosis is an iron-dependent form of programmed cell death triggered by unrestricted lipid peroxidation and subsequent plasma membrane rupture

Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis

Supplementation has been linked to increased expression of slit diaphragm proteins such as nephrin and podocin, as well as reduced tubular injury, possibly through anti-inflammatory and anti-RAAS mechanisms ( Taken together, these findings suggest that vitamin D exerts renal protection in CKD not only through inflammation, oxidative stress, and fibrosis regulation but also via its roles in autophagy, Klotho signaling, and podocyte stability, highlighting its broader therapeutic potential (Figure 3)

Overexpression of TFEB can rescue this phenotype by promoting lysosomal biogenesis and A trafficking

It generally appears first in the hands and feet

Nacystelyn, a novel lysine salt of n-acetylcysteine, to augment cellular antioxidant defence in vitro