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As previously discussed, the EOS of AUD individuals is characterized by increased PDYN because of methylation at particular SNPs in the PDYN promoter, which promotes anxiogenesis (39)

Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: modulation of C/EBP- and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects [J]

J Biol Chem 266:40294032

10.1111/j.1365-2567.2010.03379.x 138

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Mohammad Sajadi Department of Statistics, University of Gujrat, Gujrat, Pakistan Mirza Rizwan Sajid Department of Integrated Health Education, Federal University of Esprito Santo, Vitria, Brazil Luciane B