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The key effects are well-established: accelerated cell turnover (the outer layers of the stratum corneum, the skin's surface barrier, shed more quickly), direct stimulation of procollagen genes, and suppression of matrix metalloproteinases - the enzymes responsible for breaking down existing collagen

In addition to these inter-protein transfer events, several of the enzymes also seem to catalyse the intra-protein transfer of disulphide bonds between their own cysteine pairs

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There are other large RCTs where similarly high doses of vitamin B 12 have been given together with other micronutrients.31 32 These studies found that the micronutrient mixture that included high doses of vitamin B 12 reduced the risk for small for gestational age (SGA) with no adverse effects

No published human clinical trials exist

Research shows particular promise for gut inflammation, skin conditions, and systemic inflammatory states