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Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

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In enzymatic reactions, proteins containing heme or Fe-S clusters interact with specific ROS-generating enzymes such as LOXs, cytochrome P450, and cyclooxygenases (COXs) to facilitate lipid peroxidation ( 2+ and can directly catalyze L-H bonds in PUFA-PEs, forming L-OO

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The three components are paired in a single product because their mechanisms are commonly framed as complementary in research and clinical-anecdote contexts: GHK-Cu modulates collagen and elastin synthesis, antioxidant gene expression, and dermal extracellular matrix remodeling