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discovered that in mouse MCs, knocking down ROCK restored impaired fatty acid metabolism by modulating metabolic regulators like AMPK, PGC-1, and CPT-1 [78]

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Despite these advances, translation into clinical practice remains limited due to challenges such as immunogenicity, systemic instability, manufacturing scalability, and regulatory complexity

Specifically, Prevotella copri produces succinic acid, which binds to succinate receptors on dendritic cells, enhancing antigen-specific T cell responses and contributing to host immune defense mechanisms (Dan et al., 2020)

however, in sarcopenia, inflammation reduces muscle tissues ability to grow in response to insulin