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While more research is necessary, repeated exposure to oscillatory hemodynamic stress and the associated patterns of shear stress on the endothelium may prime the vasculature to better handle both surges and sudden drops in systemic blood pressure, potentially leading to better maintenance and regulation of CBF during pressure challenges

doi: 10.1158/2326-6066.CIR-20-0968 29 LeeJJKangHJKimSSChartonCKimJLeeJ-K

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

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Neuron 109 , 31043118.e6 (2021)

Insights into pathophysiology and therapeutic strategies for heat stroke: lessons from a baboon model