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Se can reduce the incidence rate of heart disease in humans, but ROS formed during oxidative stress can initiate lipid peroxidation, damage normal cell function, and lead to myocardial ischemia reperfusion (I/R) injury

Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex

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However, Tim-AIII-mediated reduction of GPX4 was reversed when cotreated with HSP90 inhibitor tanespimycin ( Fig