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Together, these studies provided strong evidence, albeit indirect, that formaldehyde accumulates endogenously

They potently attenuate ROS accumulation and oxidative stress in dopaminergic cells, thereby preventing the depletion of endogenous antioxidants

These categories and their representative examples are illustrated in Figure 2

At the relevant pH for bioconjugation (pH 8), 40% of maleimide hydrolysed to non-reactive maleic acid limiting further downstream application of these compounds

Studies by Cao, X et al

Renewed interest has uncovered strong ties to the immune system, as these antioxidant properties have been shown to support a healthy inflammatory response, particularly in lung tissue