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Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice

Supporting a major role of oxidant stress in the thrombogenicity of moderate hyperhomocysteinemia, pretreatment by antioxidants prevents acute methionine load-induced endothelial and platelet dysfunctions in healthy subjects (Chambers et al, 1999

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FcR1-expressing nociceptors trigger allergic airway inflammation

Therefore, we summarize the current knowledge regarding the mechanisms involved in the regulation of ferroptosis for further discussion of its role in the pathogenesis and prognosis of skin diseases

By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production