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5-MTHF is the active form of folate, the most common circulating form of folate, and a methyl donor for homocysteine remethylation to methionine

doi: 10.1093/neuonc/noaa198 64 QuailDFBowmanRLAkkariLQuickMLSchuhmacherAJHuseJTet al

Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival

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ROS accumulation also induces mitochondrial DNA lesions, strand breaks, and DNA degradation (42)