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Current Pharmaceutical Design, 20(7), 1413-1419

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S100A2 protein is a direct transcriptional target of p73 and Np63, which both are required for the developmental and differentiation processes of keratinocytes (55)

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(2016) 11:e0146750

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This is particularly relevant in PD where sustained microglial activation in inflammasome signaling intensifies oxidative stress, disrupts synaptic integrity and accelerates dopaminergic cell loss

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Semaglutide activates only GLP-1 receptors, while tirzepatide activates both GLP-1 and GIP receptors, offering dual-pathway weight loss signaling

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Additionally, serum GFAP levels are associated with severe functional outcomes and mortality at 6 months (Lei et al., 2015)

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