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Hormonal Imbalances Thyroid hormone imbalances, such as hypothyroidism , reduce methylation efficiency by affecting metabolic processes and enzyme activities

Eosin staining was carried out for 1 min, followed by rinsing under running water

In a rat model of arsenic-induced injury, the hippocampus was treated with ellagic acid, which was shown to regulate total ROS production, apoptosis markers, BAX and Bcl2, and inflammatory markers IL-1, TNF, and INF

Psoriasis is also associated with systemic oxidative stress, which occurs when antioxidant defense mechanisms fail to counterbalance reactive oxygen and nitrogen species (ROS/RNS) 8,9,10

Nat Commun 2013;4:1829

Overall signal: Reviews summarize broad preclinical benefits but emphasize minimal human data and the need for trials before clinical adoption