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In bladder cancer, it induces ferroptosis mainly by inhibiting GPX4 expression (68)

495 However, DHODH inhibition in SOD2-depleted cells reduced oxidative stress, lipid peroxidation, and ferroptosis, improving survival and colony formation, suggesting that DHODH activity sustains radiation-induced ferroptosis

To exert a bacteriostatic effect, the metabolites bind to bacterial ribosomes and stop protein synthesis in addition to inhibiting enzymes involved in the citric acid cycle and those in charge of DNA and RNA synthesis

Moreover, B vitamins such as B6 and B12 play roles in neurotransmitter production and brain function

nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis

PARPs (poly(ADP-ribose) polymerases) use large amounts of cellular NAD+ during DNA damage repair