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3.2.5 Valvular heart disease Valvular heart disease can be categorized into primary and secondary types

Clin Exp Immunol (2013) 171(3):28397

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variable domains of naturally occurring heavy and light chains each comprise four FRM regions (FR1 , FR2, FR3, and FR4), largely adopting a -sheet configuration, connected by three hypervariable regions, which form loops connecting, and in some cases forming part of, the -sheet structure

DBAN does not hinder ongoing DNA replication, but specifically blocks the serine 345 phosphorylation of the DNA damage checkpoint kinase Chk1 by Rad3 (ATR) at broken replication forks