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Orange-pigmented produce is most famous for its high levels of vitamin A, which is made in the body after consumption of the carotenoids, namely beta carotene

American journal of mens health , 13 (2), 1557988319835985

In particular, considering that both of these transcription factors also play critical roles in normal cell physiology, elucidating the common signaling pathways associated with their increase in tumors and revealing the molecular mechanisms underlying the correlation between these factors are expected to enable the development of the selective regulation of HIFs and NRF2 in cancers