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Because alpha-lipoic acid is involved in so many different antioxidant functions in virtually all body tissues, it has been called the universal antioxidant

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Moreover, ascorbate promotes the synthesis and activation of antioxidant enzymes, like SOD, CAT, and GPx, and it enhances transcription factors, like Nrf2, redox factor-1 (Ref-1) and activator protein 1 (AP-1), which regulate antioxidant gene expression [217]

This group is inherently reactive, which is precisely what makes glutathione effective as an antioxidant, and precisely what makes it vulnerable during oral administration