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Many protocols suggest the following structure: Monday through Friday : Daily TB-500 injections Saturday and Sunday : Rest days Duration : 4-12 week cycles followed by rest periods Some treatment plans specify injections every 3.5 days rather than daily administration .[1] This less frequent approach can be particularly beneficial for those who prefer fewer injections while maintaining therapeutic benefits

Together, these data suggest that in most CRPC subtypes, AR directly binds and represses the BCL-2 locus in a ligand-dependent manner and inhibition of AR signaling would block AR occupancy at key regulatory regions such as ARBS1 allowing for transcriptional activation of BCL-2

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