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Serotonin promoted hepatocyte proliferation in vivo after APAP challenge As the former study showed that serotonin could promote the liver regeneration and hepatocyte proliferation after partial hepatectomy and hepatic ischemia/reperfusion injury 15,16 , we hypothesized that serotonin might also increase hepatocyte proliferation after the APAP overdose

*Correspondence: Daolin Tang, [email protected] This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In vivo and in vitro evidence confirms that acute alcohol intake can stimulate autophagy in hepatocytes, which may be directly related to the activation of the CYP2E1 pathway and the generation of ROS (Salete-Granado et al., 2023)

This condition ranks among the most prevalent critical illnesses, characterized by a reduced glomerular filtration rate, accumulation of nitrogenous waste products, disturbances in water and electrolyte balance, and acid-base imbalance as its primary clinical features

For the enrichment analysis at dendrites and axons, the mean TNR fluorescence intensity was calculated for all image segments in concentric circles of increasing radii

+ The injection can have an excellent effect with dietary therapy, exercise