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Additionally, NRF2 also regulates the expression of the solute carrier family 7 member 11 (SLC7A11), which encodes the cystine/glutamate transporter XCT [23]

FIGURE 1 Mitochondrial ISC biogenesis has two functions: (1) to synthesize functional clusters in the mitochondria, and (2) to provide an essential precursor to the CIA pathway via the inner membrane exporter ABCB7 (Lill et al., 2015)

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Oncotarget 7:7463074647 Seiler A, Schneider M, Forster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Radmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

2.3 PBPK model validation 2.3.1 PBPK model validation: PK simulations for S-CIT To validate the developed PBPK model of S-CIT, eleven clinical datasets (seven single-dose studies and four multiple-dose studies) were used