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Pre-clinical studies therefore typically employ moderately hypofractionated or ablative regimens (Demaria and Formenti, 2012

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Direct Metabolic Effects Lipolysis and Insulin Antagonism Beyond IGF-1-mediated anabolic effects, HGH 191AA exerts direct metabolic actions via GHR signalling: stimulating lipolysis in adipose tissue (increasing free fatty acid mobilisation), promoting nitrogen retention and protein synthesis in muscle, and antagonising insulin signalling producing a relative insulin resistance in peripheral tissues that directs metabolic substrate use towards fat oxidation and spares carbohydrate for glucose-dependent tissues

Food Res Int 126:108616 Beecher GR (2003) Overview of dietary flavonoids: nomenclature, occurrence and intake

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