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Danuglipron, Pfizer's oral GLP-1 agonist, has had a more challenging development path, with an initial twice-daily formulation producing significant nausea rates that led to reformulation as a once-weekly oral tablet

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Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter

According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness

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