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3.5 Cancers Currently, metabolic rewiring, which supports unrestricted proliferation and metastatic progression of cancer cells, is widely accepted to be an emerging hallmark of cancers (Petvri et al., 2020)

Quantification of Iba1 + cells was performed using ImageJ software, with results expressed as fluorescence intensity per mm 2 or mean fluorescence intensity (MFI)

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SeNPs are known to cross the BBB as any other nanoparticles and therefore, targeted delivery of SeNPs to affected regions of the brain are possible

This copper-dependent form of cell death is known as cuproptosis (13)