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Lin R, Lang M, Heinsinger N, Stricsek G, Zhang J, Iozzo R, Rosenwasser R, Iacovitti L

Signal Transduction Targeted Ther (2018) 3:110

Buckner FS: Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections

Every protocol includes a clinical consultation, structured dosing cycles, and ongoing monitoring

The reasons why patients benefit from lymphodepletion prior to ACT are not fully understood, and co-depletion of regulatory cells [26], an increase of serum cytokines [27,28], and tolerization towards xenogeneic sequences [29] have been discussed

This represents a potential caveat for the translation of preclinical into clinical research, which is further emphasized by the well-documented differences in responses to medication across ALS phenotypes (164)