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For fine lines and general skin quality on the face, topical products are a reasonable approach

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Some genetic diseases that involve defects of transcobalamin, methylmalonyl CoA mutase, or enzymes in the pathway of cobalamin adenosylation, may also result in vitamin B12 deficiency (IOM, 2000)

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The most common route is subcutaneous injection, which is relatively painless and has a lower risk of side effects