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Key review articles encapsulate the skepticism towards the ANLS hypothesis, arguing that the stoichiometric requirements, kinetics of lactate transport, and in vivo metabolic data do not support a major role for lactate shuttling in meeting neuronal energy demands during activation (Dienel, 2012, 2017, 2019)

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Since enhanced collagen mRNA levels were also observed in the tumors from vitamin C-treated mice, this suggests that gene regulatory mechanisms are also involved

Pediatrics, 142(2), e20181410

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It should be noted that this is one of the few functional clinics that allows any direct insurance billing, which has made it far more accessible to me