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Phentermine may also increase resting energy expenditure slightly, though appetite suppression remains the dominant mechanism driving weight loss

Endocrinology 140:53915401 Glowinski J, Kemel ML, Desban M, Gauchy C, Lavielle S, Chassaing G, Beaujouan JC, Tremblay L (1993) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors

doi: 10.1155/2013/687197 3 ThomfordNESenthebaneDARoweAMunroDSeelePMaroyiAet al

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The long-term safety profile is well-characterized, and the cardiovascular benefit is proven through the SELECT trial