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ALD is among the leading causes of end-stage liver disease, and its progression is closely associated with oxidative stress, inflammation, and mitochondrial dysfunction, including imbalances in the NAD + /NADH ratio [3, 4]

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Here, we investigated the analgesic effect of nicotine and indicated that nicotine may alleviate the peripheral nerve regeneration process and pain through regulating PTEN and the downstream inflammation-related pathway