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These interventions often focus on cellular and molecular pathways that target the hallmark of aging, such as those related to inflammation, oxidative stress, DNA stability, mitochondrial dysfunction, and cellular senescence ( 5.1.1 Rapamycin Rapamycin, a macrolide compound derived from Streptomyces hygroscopicus , has attracted attention not only for its effective immunosuppressive properties but also for its impact on longevity, as it is the first pharmacological compound shown to extend lifespan in mammals ( 5.1.2 Metformin Metformin, a widely prescribed antidiabetic medication known for its broad efficacy in managing glucose metabolism, is emerging as one of the most promising gerotherapeutic drugs due to its potential role in extending lifespan

doi: 10.3389/fnut.2023.1168049 Received 17 February 2023 Accepted 03 April 2023 Published 28 April 2023 Volume 10 - 2023 Edited by Ftima Martel, University of Porto, Portugal Reviewed by Wuyang Huang, Jiangsu Academy of Agricultural Sciences (JAAS), China